Non-isotopic Labeling Reagents and Kits
Enzo Life Sciences Akt inhibitor VIII (1mg). CAS: 612847-09-3
A cell-permeable compound that potently, selectively and reversibly inhibits Akt1/Akt2/Akt3 activity. Alternative name: Akti-1/2, Isozyme-selective Akt inhibitor VIII, 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Imidazoquinoxaline 16h. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO or methanol. Long Term Storage: -80°C.
Enzo Life Sciences Syk inhibitor (5mg). CAS: 622387-85-3
Alternative name: Spleen tyrosine kinase inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, K00564a. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences Simvastatin. sodium salt (10mg). CAS: 101314-97-0
Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. Simvastatin also suppresses TNF-induced NF-κB activation, which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. Alternative name: (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid . monosodium salt. Purity: ≥97% (HPLC). Solubility: Soluble in water. Long Term Storage: -80°C.
Enzo Life Sciences Cabozantinib (10mg). CAS: 849217-68-1
Cabozantinib is a very potent inhibitor, with an IC50 of less than 10 nM for VEGFR2, MET, Kit and FLT3-ITD. Alternative name: XL184, BMS-907351, N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO (100mg/ml) or ethanol (1mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences WH-4-023 (10mg). CAS: 837422-57-8
Alternative name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences KU55933 (5mg). CAS: 587871-26-9
KU55933 is a potent and selective ATP-competitive inhibitor of ATM, with an IC50 of 13 nmol/l and a Ki of 2.2 nmol/l. KU55933 has potential for use as a new radio- and chemo-sensitizing agent for the treatment of cancer. Alternative name: ATM kinase inhibitor, 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO (50 mg/ml) or ethanol (<13 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences BX795 (5mg). CAS: 702675-74-9
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM). Alternative name: N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (118mg/ml) or ethanol (1mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences GSK-3 inhibitor XIII (5mg). CAS: 404828-08-6
Alternative name: (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences C5a receptor antagonist W-54011 (1mg). CAS: 405098-33-1
Alternative name: N-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide . HCl. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO or methanol. Long Term Storage: -80°C.
Enzo Life Sciences WYE-132 (1mg). CAS: 1144068-46-1
A highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Shows an anti-proliferative activity against a variety of tumor cell lines. WYE-132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. Alternative name: 1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea, WYE-125132. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences NSC697923 (5mg). CAS: 343351-67-7
Alternative name: 2-[(4-Methylphenyl)sulfonyl]-5-nitro-furan, 2-Nitro-5-tosylfuran . Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences AGK7 (SIRT2 inhibitor, inactive control) (10mg). CAS: 304896-21-7
Can be used as an inactive control in experiments with AGK2. Alternative name: SIRT2 Inhibitor (inactive control). Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -80°C.
Enzo Life Sciences Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE™) (Ready-to-Use) (1ml)
Adjuvant Alternative name: MPL-A from Salmonella minnesota R595 (Re). Formulation: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water. Purity: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable). Long Term Storage: +4°C.
Enzo Life Sciences VDM-11 (50mg). CAS: 313998-81-1
Selective and potent inhibitor of the anandamide membrane transporter (AMT) (neuronal (C6 glioma cells): IC50=11µM; non-neuronal (rat RBL-2H3 cells): IC50=7.2µM) with negligible action at TRPV1 and weak action at CB1 receptor (CB1: Ki=5µM; CB2: Ki>5µM) and FAAH (IC50=3.7µM/ IC50>50µM (N18TG2 cell membranes). Alternative name: N-Arachidonoyl-4-hydroxy-2-methylaniline, N-(4-Hydroxy-2-methylphenyl)arachidonoylamide. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (1.5mg/ml) or ethanol (1mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences PF-356231 (5mg). CAS: 766536-21-4
Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml). Long Term Storage: -20°C.